한국어 
Calycosin-7-O-β-D-glucoside (CAS: 20633-67-4) is a bioactive isoflavone glycoside primarily derived from Astragalus membranaceus roots, widely used in pharmaceutical research and nutraceutical development. With molecular formula C₂₂H₂₂O₁₀ (MW: 446.4), this compound demonstrates significant antioxidant and anti-inflammatory properties.
제품명 :
Calycosin-7-O-β-D-glucopyranosideCAS 번호 :
20633-67-4모습 :
Fine White Powder사양 :
98%Synonyms: Calycosin 7-glucoside, Calycosin-7-O-β-D-glucopyranoside
CAS No.: 20633-67-4
Molecular Formula: C₂₂H₂₂O₁₀
Molecular Weight: 446.40 g/mol
Botanical Source: Astragalus membranaceus (Huangqi) root extract
✅ Dual-Target Bioactivity: Estrogenic Modulation + Anti-Inflammation
Selective ERβ Agonist: Binds to estrogen receptor beta (Ki = 0.38 μM), alleviating menopausal symptoms without uterine stimulation .
NF-κB Pathway Inhibitor: Reduces pro-inflammatory cytokines (IL-6/TNF-α ↓45%) in macrophage models .
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD) |
| Appearance | Off-white crystalline powder |
| Solubility | Soluble in DMSO, methanol; Sparingly soluble in water (0.5 mg/mL) |
| Storage | -20°C in amber glass vial, under nitrogen |
| Shelf Life | 24 months (accelerated stability confirmed) |
| Key Physicochemical Properties | • Melting Point: 228-230°C • Log P: 1.82 ±0.05 |
Menopausal Health
Efficacy: Reduces hot flash frequency by 52% (vs. placebo 18%) in 8-week trial (40 mg/day) .
Safety: No endometrial hyperplasia risk (ERα/ERβ selectivity ratio >12) .
Cardiovascular Protection
Vasodilation: Enhances NO production by 80% in HUVECs, improving endothelial function .
Antioxidant: Scavenges •OH radicals (IC₅₀ = 7.4 μM), preventing LDL oxidation .
Dermatological Benefits
Collagen Synthesis: Upregulates COL1A1 expression by 3.2-fold in fibroblasts .
UV Barrier: Suppresses MMP-1 by 67% in UV-irradiated skin models .
| Sector | Formulation Examples |
|---|---|
| Pharmaceuticals | - Menopause relief capsules (20-60 mg/day) - Cardioprotective injectables (with phospholipid complex) |
| Cosmeceuticals | - Anti-redness serums (0.2-1% w/w) - Collagen-boosting creams |
| Nutraceuticals | - Women's health supplements (blended with black cohosh) - Vascular support functional beverages |
🔬 Advanced Extraction Technology
Chromatographic Purification: Multi-step HPLC (C18 column) yielding >99% peak area purity .
Impurity Control: Astragaloside IV <0.5%, heavy metals <0.1 ppm (ICP-MS verified) .
🌿 Sustainable Sourcing & Traceability
Origin: Cultivated in GAP-certified Astragalus farms (Shanxi, China) with blockchain traceability .
Extraction: Ethanol/water (70:30) low-temperature extraction, preserving glycoside integrity .
🌐 Certifications & Compliance
ISO 9001:2015, ISO 17025 (CNAS-CL01 testing lab)
Full Dossier: COA (with chromatogram), SDS, Non-GMO Declaration, Allergen Statement
| Quantity | Primary Packaging | Shipping Conditions |
|---|---|---|
| 50mg–1g | Amber glass vial + argon gas | Cold chain (2-8°C) |
| 1g–50g | Vacuum foil bag in desiccator | Dry ice |
| >50g | HDPE drum with oxygen absorber | -20°C freezer |
Q: Is batch-specific stability data available?
A: Yes, each COA includes 24-month accelerated stability data (ICH Q1A guidelines) for humidity/light/temperature.
Q: Can you provide water-soluble formulations?
A: We offer:
Hydroxypropyl-β-cyclodextrin complexes (water solubility >20 mg/mL)
Liposomal nanoemulsions for enhanced bioavailability
Q: Minimum order for R&D samples?
A: 50mg (≥98%), shipped with full characterization data (NMR, MS, HPLC).
Bioactivity Guarantee: Lot-to-lot consistency verified by ERβ binding assay (EC₅₀ = 0.42±0.07 μM).
End-to-End Solutions: From bulk powder to ready-to-use formulations (gels, capsules, liquids).
시클로아스트라게놀황기(Astragalus membranaceus)에서 추출한 강력한 트리테르페노이드인 는 텔로머라제 활성화, 항노화 및 면역 조절에 대한 임상 연구가 진행 중입니다. 당사의 수직 통합 공정은 HPLC 검증 순도(50%-98%)를 제공하며, ISO 인증 품질 관리를 통해 뒷받침됩니다. 세포 장수를 목표로 하는 건강기능식품, 피부 탄력을 위한 코스메슈티컬, 그리고 제약 R&D에 이상적입니다. 지금 바로 샘플을 신청하세요!
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